WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:MAPK signaling pathway       ID:04010
C=268; O=15; E=0.96; R=15.57; rawP=6.73e-14; adjP=3.70e-12
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000158050 NA DUSP2 dual specificity phosphatase 2 1844 ENSG00000158050
3  ENSG00000073803 NA MAP3K13 mitogen-activated protein kinase kinase kinase 13 9175 ENSG00000073803
4  ENSG00000123358 NA NR4A1 nuclear receptor subfamily 4, group A, member 1 3164 ENSG00000123358
5  ENSG00000136997 NA MYC v-myc myelocytomatosis viral oncogene homolog (avian) 4609 ENSG00000136997
6  ENSG00000107968 NA MAP3K8 mitogen-activated protein kinase kinase kinase 8 1326 ENSG00000107968
7  ENSG00000099860 NA GADD45B growth arrest and DNA-damage-inducible, beta 4616 ENSG00000099860
8  ENSG00000221823 NA PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 5534 ENSG00000221823
9  ENSG00000104856 NA RELB v-rel reticuloendotheliosis viral oncogene homolog B 5971 ENSG00000104856
10  ENSG00000077150 NA NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 4791 ENSG00000077150
11  ENSG00000170345 NA FOS FBJ murine osteosarcoma viral oncogene homolog 2353 ENSG00000170345
12  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
13  ENSG00000138166 NA DUSP5 dual specificity phosphatase 5 1847 ENSG00000138166
14  ENSG00000120129 NA DUSP1 dual specificity phosphatase 1 1843 ENSG00000120129
15  ENSG00000130522 NA JUND jun D proto-oncogene 3727 ENSG00000130522


Database:KEGG pathway       Name:Osteoclast differentiation       ID:04380
C=128; O=11; E=0.46; R=23.91; rawP=1.53e-12; adjP=2.80e-11
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000171223 NA JUNB jun B proto-oncogene 3726 ENSG00000171223
3  ENSG00000125740 NA FOSB FBJ murine osteosarcoma viral oncogene homolog B 2354 ENSG00000125740
4  ENSG00000104856 NA RELB v-rel reticuloendotheliosis viral oncogene homolog B 5971 ENSG00000104856
5  ENSG00000075426 NA FOSL2 FOS-like antigen 2 2355 ENSG00000075426
6  ENSG00000077150 NA NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 4791 ENSG00000077150
7  ENSG00000170345 NA FOS FBJ murine osteosarcoma viral oncogene homolog 2353 ENSG00000170345
8  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
9  ENSG00000175592 NA FOSL1 FOS-like antigen 1 8061 ENSG00000175592
10  ENSG00000130522 NA JUND jun D proto-oncogene 3727 ENSG00000130522
11  ENSG00000184557 NA SOCS3 suppressor of cytokine signaling 3 9021 ENSG00000184557


Database:KEGG pathway       Name:Cytokine-cytokine receptor interaction       ID:04060
C=265; O=14; E=0.95; R=14.70; rawP=1.04e-12; adjP=2.80e-11
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000125845 NA BMP2 bone morphogenetic protein 2 650 ENSG00000125845
3  ENSG00000128342 NA LIF leukemia inhibitory factor 3976 ENSG00000128342
4  ENSG00000108342 NA CSF3 colony stimulating factor 3 (granulocyte) 1440 ENSG00000108342
5  ENSG00000108691 NA CCL2 chemokine (C-C motif) ligand 2 6347 ENSG00000108691
6  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
7  ENSG00000108700 NA CCL8 chemokine (C-C motif) ligand 8 6355 ENSG00000108700
8  ENSG00000163734 NA CXCL3 chemokine (C-X-C motif) ligand 3 2921 ENSG00000163734
9  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429
10  ENSG00000163739 NA CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 ENSG00000163739
11  ENSG00000081041 NA CXCL2 chemokine (C-X-C motif) ligand 2 2920 ENSG00000081041
12  ENSG00000173530 NA TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 8793 ENSG00000173530
13  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
14  ENSG00000099985 NA OSM oncostatin M 5008 ENSG00000099985


Database:KEGG pathway       Name:Malaria       ID:05144
C=51; O=8; E=0.18; R=43.65; rawP=1.30e-11; adjP=1.79e-10
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000108342 NA CSF3 colony stimulating factor 3 (granulocyte) 1440 ENSG00000108342
3  ENSG00000108691 NA CCL2 chemokine (C-C motif) ligand 2 6347 ENSG00000108691
4  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
5  ENSG00000007908 NA SELE selectin E 6401 ENSG00000007908
6  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429
7  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
8  ENSG00000090339 NA ICAM1 intercellular adhesion molecule 1 3383 ENSG00000090339


Database:KEGG pathway       Name:NOD-like receptor signaling pathway       ID:04621
C=58; O=8; E=0.21; R=38.38; rawP=3.82e-11; adjP=4.20e-10
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000163739 NA CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 ENSG00000163739
3  ENSG00000081041 NA CXCL2 chemokine (C-X-C motif) ligand 2 2920 ENSG00000081041
4  ENSG00000118503 NA TNFAIP3 tumor necrosis factor, alpha-induced protein 3 7128 ENSG00000118503
5  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
6  ENSG00000108691 NA CCL2 chemokine (C-C motif) ligand 2 6347 ENSG00000108691
7  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
8  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429


Database:KEGG pathway       Name:Rheumatoid arthritis       ID:05323
C=91; O=8; E=0.33; R=24.46; rawP=1.53e-09; adjP=1.40e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000163739 NA CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 ENSG00000163739
3  ENSG00000170345 NA FOS FBJ murine osteosarcoma viral oncogene homolog 2353 ENSG00000170345
4  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
5  ENSG00000108691 NA CCL2 chemokine (C-C motif) ligand 2 6347 ENSG00000108691
6  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
7  ENSG00000090339 NA ICAM1 intercellular adhesion molecule 1 3383 ENSG00000090339
8  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429


Database:KEGG pathway       Name:African trypanosomiasis       ID:05143
C=35; O=5; E=0.13; R=39.75; rawP=1.67e-07; adjP=1.31e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
3  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
4  ENSG00000007908 NA SELE selectin E 6401 ENSG00000007908
5  ENSG00000090339 NA ICAM1 intercellular adhesion molecule 1 3383 ENSG00000090339


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=10; E=1.17; R=8.53; rawP=3.31e-07; adjP=2.28e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000125845 NA BMP2 bone morphogenetic protein 2 650 ENSG00000125845
2  ENSG00000073756 NA PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5743 ENSG00000073756
3  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
4  ENSG00000136997 NA MYC v-myc myelocytomatosis viral oncogene homolog (avian) 4609 ENSG00000136997
5  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429
6  ENSG00000068028 NA RASSF1 Ras association (RalGDS/AF-6) domain family member 1 11186 ENSG00000068028
7  ENSG00000077150 NA NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 4791 ENSG00000077150
8  ENSG00000123374 NA CDK2 cyclin-dependent kinase 2 1017 ENSG00000123374
9  ENSG00000076604 NA TRAF4 TNF receptor-associated factor 4 9618 ENSG00000076604
10  ENSG00000170345 NA FOS FBJ murine osteosarcoma viral oncogene homolog 2353 ENSG00000170345


Database:KEGG pathway       Name:Jak-STAT signaling pathway       ID:04630
C=155; O=7; E=0.56; R=12.57; rawP=1.61e-06; adjP=9.84e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000128342 NA LIF leukemia inhibitory factor 3976 ENSG00000128342
2  ENSG00000108342 NA CSF3 colony stimulating factor 3 (granulocyte) 1440 ENSG00000108342
3  ENSG00000137193 NA PIM1 pim-1 oncogene 5292 ENSG00000137193
4  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
5  ENSG00000136997 NA MYC v-myc myelocytomatosis viral oncogene homolog (avian) 4609 ENSG00000136997
6  ENSG00000184557 NA SOCS3 suppressor of cytokine signaling 3 9021 ENSG00000184557
7  ENSG00000099985 NA OSM oncostatin M 5008 ENSG00000099985


Database:KEGG pathway       Name:Toll-like receptor signaling pathway       ID:04620
C=102; O=6; E=0.37; R=16.37; rawP=1.98e-06; adjP=1.09e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000170345 NA FOS FBJ murine osteosarcoma viral oncogene homolog 2353 ENSG00000170345
3  ENSG00000125538 NA IL1B interleukin 1, beta 3553 ENSG00000125538
4  ENSG00000136244 NA IL6 interleukin 6 (interferon, beta 2) 3569 ENSG00000136244
5  ENSG00000107968 NA MAP3K8 mitogen-activated protein kinase kinase kinase 8 1326 ENSG00000107968
6  ENSG00000169429 NA IL8 interleukin 8 3576 ENSG00000169429




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).